The trilinear Higgs coupling $\lambda_{hhh}$ is a crucial tool to probe the structure of the Higgs potential and to search for possible effects of physics beyond the Standard Model (SM). Focusing on the Two-Higgs-Doublet Model as a concrete example, we identify parameter regions in which $\lambda_{hhh}$ is significantly enhanced with respect to its SM prediction. Taking into account all relevant corrections up to the two-loop level, we show that current experimental bounds on $\lambda_{hhh}$ already rule out significant parts of the otherwise unconstrained parameter space. We illustrate the interpretation of the current results and future measurement prospects on $\lambda_{hhh}$ for a benchmark scenario. Recent results from direct searches for BSM scalars in the $A\to ZH$ channel and their implications will also be discussed in this context.