We present results for the isospin-0 $\pi\pi$ s-wave scattering length calculated in twisted mass lattice
QCD. We use three $N_f = 2$ ensembles with unitary pion mass at its physical value, 240~MeV and 330~MeV respectively. We also use a large set of $N_f = 2 + 1 +1$ ensembles with unitary pion masses varying in the range
of 230~MeV - 510~MeV at three different values of the lattice
spacing. A mixed action approach with the Osterwalder-Seiler action in the valence sector is adopted to circumvent the complications arising from isospin symmetry breaking of the twisted mass quark action. Due to the relatively large lattice artefacts in the $N_f = 2 + 1 +1$ ensembles, we do not present the scattering lengths for these ensembles. Instead, taking the advantage of the many different pion masses of these ensembles, we qualitatively discuss the pion mass dependence of the scattering properties of this channel based on the results from the $N_f = 2 + 1 +1$ ensembles. The scattering length is computed for the $N_f = 2$ ensembles and the chiral extrapolation is performed. At the physical pion mass, our result $M_\pi a^\mathrm{I=0}_0 = 0.198(9)(6)$ agrees reasonably well with various experimental measurements and theoretical predictions.