Recently, a lot of models have appeared to confront the data from dark matter searches with microscopical constraints from accelerators, primordial Universe, or astrophysical observations. From Higgs portal, to Z' portal, passing through Z-portal, the scenarios begin to be severely restricted due to the precision measurements of direct or indirect searches. We will concentrate on this proceeding in the Z' extension in the framework of unified SO(10)/GUT theory, using the complementarity of the constraints as a powerful tool to derive stringent bounds on the viable parameter space of the model.