The implications of indirect searches through rare $B$ decays is presented in Two Higgs Doublet Models, with an emphasis on the recent LHCb measurements. A comparison with the direct LHC search constraints is also provided. In particular, in 2HDM of Type II, we find that flavour physics observables impose a combined lower limit on the charged Higgs mass of $M_{H^\pm} \gtrsim 600$ GeV - independent of $\tan\beta$ - which increases to $M_{H^\pm} \gtrsim 650$ GeV for $\tan\beta < 1$.