The Mini-EUSO instrument is an UV telescope to be placed aboard the International Space Sta-tion (ISS) in the framework of the JEM-EUSO project. Mini-EUSO will map the Earth in the UV range (300 - 400 nm) with a spatial resolution of 5 km and a temporal resolution of 2.5 μs.
Therefore, Mini-EUSO offers an excellent opportunity to study a variety of physics phenomena such as transient luminous events and meteors, as well as searching for strange quark matter and test the detection of space debris. Mini-EUSO will serve also as a pathfinder for the study of Extreme Energy Cosmic Rays from space. A review on the expected performance of Mini-EUSO in detecting a variety of physical phenomena simulated with the EUSO Simulation and Analysis Framework (ESAF) package is described.