We present a novel analysis method and performance studies to determine the neutrino-nucleon
deep-inelastic scattering cross section at high energies. The analysis uses atmospheric and extraterrestrial
neutrino-induced electromagnetic and hadronic showers (cascades) in the TeV-PeV
energy range, and assumes that the extraterrestrial neutrino flux is isotropic. Signal samples are
separated into two groups, "down-going" (from the Southern Hemisphere) and "up-going" (from
the Northern Hemisphere). Since up-going events may interact and be absorbed by the Earth while
down-going event rate remains unaffected, the ratio of down-going events and up-going events
for certain energy range is correlated with the cross section value. At the energies in this study,
the yields are sensitive to the neutrino-nucleon cross section and nucleon structure in a region of
kinematic overlap with HERA and with the LHC.We present the method for the neutrino-nucleon
cross section measurement in the TeV-PeV energy range using neutrino induced cascades with the
complete IceCube detector. In addition, we will test the hypothesis of a North-South anisotropy in
astrophysical neutrino flux, assuming the knowledge of the neutrino-nucleon cross section from
the electroweak physics.