The High Twist approach has been used to calculate parton energy loss and the medium modified fragmentation function due to multiple parton scattering. We revisit this problem for the deeply inelastic scattering (DIS) process with a Generalized High Twist approach. In this approach, the differential radiated gluon number distribution can be expressed in terms of the unintegrated gluon distribution function, or the transverse momentum dependent jet transport coefficient. The radiated gluon spectrum can be calculated without soft gluon and static medium approximation. In these limits, one can recover the GLV result in first order opacity approximation.