The precise measurement of cosmic-ray antiparticles and antinuclei serves as important means for identifying the nature of dark matter and other beyond-standard-model physics. Recent years showed that identifying the nature of dark matter with cosmic-ray positrons and antiprotons is difficult, and has lead to a significantly increased interest in cosmic-ray antideuteron and antihelium searches. Antideuterons and antihelium nuclei may also be generated in dark matter annihilations or decays, offering a potential breakthrough in unexplored phase space for dark matter. Low-energy antinuclei are an important approach because the flux from dark matter interactions exceeds the background flux by orders of magnitude in the low-energy range for a wide variety of models without relying on any boosting mechanisms. This talk summarizes the results of the ``2nd Cosmic-ray Antideuteron Workshop" that was held in March 2019 and brought together theorists and experimentalists in the field to discuss the current status, perspectives, and challenges for cosmic-ray antinuclei searches. It will review the motivation for antinuclei searches, the experimental status and its interpretation, as well as discuss some of the theoretical and experimental uncertainties of antinuclei production and propagation in our Galaxy.