The BESIII experiment at the BEPCII storage ring has accumulated the world's largest data samples in the tau-charm energy region, that are used for investigations of conventional and exotic hadrons, weak decays of the charmed particles, and searches for new physics. In this talk, we report the recent progress in these fields, including new results about the charmoniumlike states X(3872), Y(4260), and Zc(390)); the glueball candidates; the pure leptonic and semileptonic decays of D and D_s; and the baryon properties produced in e+e- annihilation.