We present the computation of two-loop Higgs plus three-parton amplitudes with dimension-seven operators in Higgs effective field theory. The computation is based on the combination of unitarity cut and integration by parts methods in an unconventional way. The analytic results take remarkably simple form. In particular, the results show that the QCD and N=4 SYM results share the same leading transcendental parts. This generalizes the so-call maximal transcendentality principle to the Higgs amplitudes with high dimension operators and also with fundamental external quark states. Further simplicity also exists in lower transcendental parts, suggesting hidden structures beyond maximal transcendentality.