A small anisotropy in the arrival directions of comic rays has been consistently observed by ground detectors based on very large sample of events. The Dark Matter Particle explorer (DAMPE) has so far accumulated more than 10 billion events above GeV with relatively high spatial and energy resolution during its 5-year plus on-obit operation, providing a good data sample for probing the anisotropy of cosmic rays. We introduce in this proceeding our optimizations in the direction measurement, data sampling and anisotropy analysis. The anisotropy predicted by the east-west effect due to the Earth magnetic field and the Compton-Getting effect due to the Earth revolution are then applied to the validation of our analysis.