We present a lattice QCD computation and preliminary results for the leptonic decay constants of the pseudoscalar mesons $K$, $D$ and $D_{s}$ in the isosymmetric QCD limit. The computation is based on simulations of $N_f= 2+1+1$ dynamical quarks performed by the Extended Twisted Mass Collaboration (ETMC), where the light, strange and charm quark masses are all tuned at their physical values. We also present preliminary unitarity checks for the first and second rows of the Cabibbo-Kobayashi-Maskawa matrix.