Modern physics experiments usually rely on very big experimental setup where it is possible to find a wide variety of detectors: silicon microstrip trackers, plastic scintillator calorimeters, LAr cryostats readout by a Time Projection Chamber, spectrometers composed of several drift tubes and resistive plate chambers. Moreover, other large and medium scale setups for the search of neutrinos and Astro-particles use thousands of scintillation detectors read out by photomultipliers or SiPMs. Nowadays, waveform digitizers and/or ASIC-based front-end cards are well-established readout electronics to build a reliable system hosting many readout channels. The FERS-5200 is the new CAEN Front-End Readout System, answering the challenging requirement to provide flexibility and cost-effectiveness in the readout of huge detector arrays. FERS-5200 is a distributed and easy-scalable platform integrating the whole readout chain of the experiment, from detector front-end to DAQ. It is based on compact ASIC-based front-end cards integrating A/D conversion and data processing, which can be ideally spread over a large detector volume without drawbacks on the readout performance. Synchronization, event building and DAQ is managed by a single Concentrator board, capable of sustaining thousands of readout channels. Using the appropriate Front-End, the solution perfectly fits a wide range of detectors such as SiPMs, multi-anode PMTs, GEMs, Silicon Strip detectors, Wire Chambers, Gas Tubes, etc, thus matching the requirements of different applications.