In this talk I will present an automated framework calculating next-to-leading (NLO) corrections in the full Standard Model (SM) for arbitrary processes at hadron and lepton colliders. This framework is an element of the Monte-Carlo program WHIZARD simulating cross sections and differential distributions. The generalization of the implemented Frixione-Kunszt-Signer (FKS) scheme to systematically subtract QED and QCD infrared divergences in mixed coupling expansions will be discussed. Also, recent progress of the POWHEG-matched event generation and the inclusion of electroweak corrections in future lepton collider processes are subjects of this talk. In particular, results of our recent study will be shown applying electroweak (EW) corrections to multi-boson processes at a future multi-TeV muon collider.