NUSES is a new space mission project aimed at studying cosmic and gamma rays, high-energy astrophysical neutrinos, the Sun-Earth environment, space weather, and magnetosphere-ionospherelithosphere coupling. Additionally, the NUSES mission will serve as a technological pathfinder for the development and testing of innovative technologies and observational strategies for future missions. The satellite will host two payloads named Terzina and Zirè. Zirè will perform measurements of electrons, protons, and light nuclei from a few up to hundreds of MeV, while also testing new tools for the detection of cosmic MeV photons and monitoring of MILC signals. The Terzina telescope aims to detect ultra-high-energy cosmic rays (UHECRs) through the Cherenkov light emission from extensive air showers that they create in the Earth’s atmosphere. The telescope will also monitor the light emissions from the Earth limb in the near-UV and visible ranges at the nanosecond timescale, thus testing the observational concept of detecting Earth skimming astrophysical high-energy neutrinos. Terzina will be able to study the potential for future physics missions (e.g. POEMMA) devoted to UHECR detection and UHE neutrino astronomy. In this talk, the status of the NUSES project design will be discussed along with the scientific and technological objectives of the mission.