We discuss the high-energy probes of flavor physics operators in the $pp\to\ell\nu$ and $pp\to \ell\ell^\prime$ processes, with $\ell,\ell^\prime \in \lbrace e,\mu,\tau \rbrace$, and explore their complementarity with low-energy flavor measurements. We consider the Standard Model Effective Field Theory (SM EFT) as our framework and we discuss two explicit examples: (i) the discrepancies observed in the $b\to c\tau \nu$ transition, and (ii) the $b\to s\nu\bar{\nu}$ decays that are currently studied at Belle-II. We also briefly comment on the current status of the SM predictions for these low-energy observables.