Over the last two decades, we have intensified our search for a ghost particle, with the hope that it would provide us with information on the darkest places of our Universe. This quest has been conducted from the deep caves of the Earth, up to the upper layers of our atmosphere, and from one Pole to another. In this review, I will summarize the odyssey of the search for astrophysical neutrinos. I will focus on the recent discoveries and technical developments that led us to the point where we stand now. I will highlight the different types of neutrino detectors, and their performances enabling the discovery of high-energy astrophysical neutrinos, and the understanding of their sources behind. Finally, I will present some possible paths to the remaining uncharted territory of the ultra-high-energy neutrino astronomy.