Moon Burst Energetics All-sky Monitor (MoonBEAM) is a gamma-ray mission concept to observe the entire sky instantaneously for relativistic astrophysical explosions from a cislunar orbit. It is designed to explore the behavior of matter and energy under extreme conditions by observing the prompt emission from gamma-ray bursts, identifying the conditions capable of launching transient relativistic jets and the origins of high-energy radiation from the relativistic outflows. MoonBEAM will achieve uninterrupted, instantaneous all-sky coverage from 10keV to 5MeV by using phoswich gamma-ray detectors and operating from a cislunar orbit. This orbit will minimize Earth blockage and background variations that are difficult to reduce in Low Earth Orbit. MoonBEAM will provide essential prompt gamma-ray observations and rapid alerts to the astronomical community for contemporaneous and follow-up observations. This presentation will give an overview of the MoonBEAM mission and its mission design, which enable sensitive high-energy all-sky observation that is critical to the transient and multi-messenger astronomy.