Radiation tolerance specifications for experiments at several future particle colliders are summarized. The role of tracking systems and timing systems in vertexing is emphasized, and so the consequences of radiation damage upon both types of systems are discussed. Challenges to vertexing that arise from radiation damage in semiconductor detectors are reviewed. Features observed in detector response at the highest controlled fluences are noted. Approaches to mitigate the effects of radiation damage and thereby achieve excellent tracking and timing are reviewed.