The proposed LUXE experiment (LASER Und XFEL Experiment) at DESY, Hamburg, using the electron beam from the European XFEL, aims to probe QED in the non-perturbative regime created in collisions between high-intensity laser pulses and high-energy electron or photon beams. This setup also provides a unique opportunity to probe physics beyond the standard model. In this talk we show that by leveraging the large photon flux generated at LUXE, one can probe axion-like-particles (ALPs) up to a mass of 350~MeV and with photon coupling of $3 \times 10^{-6}$~GeV$^{-1}$. This reach is comparable to the background-free projection from NA62. In addition, we will discuss other probes of new physics such as ALPs-electron coupling.