Precision luminosity measurements are essential to determine the fundamental properties of the physics processes at the LHC. The estimation of the integrated luminosity at the CMS experiment requires absolute scale calibration of the luminometers, which is derived under special LHC machine setup. Series of beam separation (van der Meer) scans are performed during these special runs. The transverse profile of the overlap between the proton beams are estimated by the continuous monitoring of the interaction rates together with the beam properties. The dominant sources of systematic calibration uncertainty are related to the precise estimation of the beam separation and the non-factorizability of the proton density distributions in the transverse direction. The correction factors and their uncertainties are extracted for each effect and propagated to determine the final absolute scale and the corresponding uncertainty. The obtained van der Meer scan calibration is applied to the full physics data-taking period in order to estimate the integrated luminosity. The latest results of the luminosity calibration studies are reported from the CMS experiment.