Hyperon-nucleon interactions are important to understand quantum chromodynamics and so-called "hyperon puzzle" of neutron star, but limited by the availability and short-lifetime of hyperon beams, the progress of relevant research is very slow. A novel method is used to study hyperon-nucleon interactions based on hyperons produced in the decays of 10 billion $J/\psi$ events collected with the BESIII detector at the BEPCII storage ring, and the target material is beam pipe. The reactions $\Xi^{0}n\rightarrow\Xi^{-}p$, $\Lambda N\rightarrow\Sigma^+X$, $\Lambda p\rightarrow\Lambda p$ and $\bar{\Lambda}p\rightarrow\bar{\Lambda}p$ have been observed and measured at BESIII. This is the first study of hyperon-nucleon interactions in electron-positron collisions and opens up a new direction for such research. Especially, antihyperon-nucleon scattering is studied for the first time.