We discuss a recent proposal for constructing ``syzygy solutions'', which play a crucial role in integration-by-parts reductions for multi-loop scattering amplitudes. We highlight a relationship between syzygies and the leading Landau singularities of Feynman diagrams and discuss how this implies that integral relations are controlled by infrared singularities. We use this insight to systematically construct highly compact, determinantal syzygy solutions, providing an explicit, simple example at one loop. We demonstrate the power of this approach by applying it to a two-loop pentabox family relevant for the NNLO corrections to $pp \rightarrow t\overline{t}H$ at the LHC.