Ultra-high-energy neutrinos provide a unique probe of the most energetic astrophysical accelerators and of particle interactions at energies far beyond those accessible in terrestrial experiments. In-ice radio detection is a promising technique for instrumenting the enormous target volumes required to observe this flux, and several next-generation radio neutrino observatories, including the planned radio extension of IceCube-Gen2, are entering their design and construction phase.
We present a differentiable end-to-end simulation and reconstruction pipeline that enables optimization of the complete detector station layout.
Building on a pipeline previously demonstrated for shallow radio stations, we extend this framework to the deep component of the IceCube-Gen2 radio array.
We optimize deep station layouts starting from both the current IceCube-Gen2 design and an alternative initial configuration, and discuss the resulting design trends as well as their robustness to initialization.

