We present our recent study on baryon-baryon ($BB$) interactions from lattice QCD with almost physical quark masses corresponding to $(m_\pi,m_K)\approx(146,525)$ MeV and large volume $(La)^4=(96a)^4\approx$ (8.1 fm)$^4$. In order to make better use of large scale computer resources, a large number of $BB$ interactions from $NN$ to $\Xi\Xi$ are calculated simultaneously. In this report, we focus on the strangeness $S=-1$ channels of the hyperon interactions by means of HAL QCD method. The coupled-channel HAL QCD method is briefly outlined. The snapshots of central and tensor potentials in $^1S_0$ and $^3S_1-^3D_1$ channels are presented for $\Lambda N$,
$\Sigma N$ (both the isospin $I=1/2, 3/2$) and their coupled-channel systems.