The LHCb and Belle collaborations have reported on some anomalies in $b \to s$ transitions, with discrepancies with the Standard Model predictions in some angular observables and branching ratios and intriguing hints for lepton universality violation. We will review the current situation and explore the proposed New Physics explanations for these tensions. We will also discuss the possible connection of the $b \to s$ anomalies to other central problems in physics, such as the dark matter of the Universe, the origin of neutrino masses or the strong CP problem.