The two-Higgs-doublet with additional scalar (2HDM$+S$) model is one proposed to account for several anomalies that have persisted and increased in significance over runs 1 and 2 at the Large Hadron Collider (LHC). In addition to this, 2HDM+$S$ also supplies a potential Dark Matter (DM) candidate coupling to the Standard Model via the $S$ boson. So far, this model has been difficult to constrain by indirect means. Here we will explore the potential of Omega Centauri, a nearby globular cluster to constrain this interesting DM model. Although such structures are generally considered to be lacking in DM, arguments have been made that this cluster is in fact the relic of a tidally stripped dwarf galaxy. In such a scenario, the DM content would be significant. Combined with its nearness, this would suggest a potential for powerful indirect DM signals. We employ both Fermi-LAT gamma-ray data, as well as MeerKAT telescope sensitivities to determine the current status of Omega Centauri as a source of indirect constraints on Weakly Interacting Massive Particles (WIMPs) in a 2HDM+$S$ scenario and for general annihilation channels.