This paper presents the results of gamma spectrometry measurements of natural radionuclides (226Ra, 232Th, and 40K) in some floor and wall ceramic tiles produced in Serbia and used in homes and workplaces. The level of radioactivity of some ceramic tiles produced in Serbia by two major manufacturers–Zorka Keramika and Toza Markovic was examined. The measured mean value of the activity concentration of 226Ra, 232Th, and 40K exceeds the average values in the world for building materials with values of 67.2±6.9 Bq kg-1 for 226Ra, 57.4±4.7 Bq kg-1 for 232Th and 808±48 Bq kg-1 for 40K. Based on these calculated values, the representative level index gamma index, associated with gamma radiation, whose average value is 0.78±0.06, and annual effective dose, whose average value is 0.117±0.009 mSv y-1 for home was obtained. Estimated values fulfill all the recommendations of the European Union for building materials, thus analyzed materials are considered not to be a health hazard for the public.