Imaging devices made from an ionization target layer of amorphous selenium (aSe) coupled to a silicon complementary metal-oxide-semiconductor (CMOS) active pixel array for charge readout are a promising technology for neutrino physics. The high spatial resolution in a solid-state target provides unparalleled rejection of backgrounds from natural radioactivity in the search for neutrinoless $\beta\beta$ decay and for solar neutrino spectroscopy with $^{82}$Se. We summarize the scientific reach of a large detector with the proposed technology, and present the current status of R&D, including results from the first CMOS sensors optimized for charge collection in aSe.