Lattice QCD determinations of hadronic matrix elements required for precision tests of the Standard Model are now approaching an accuracy where the electromagnetic interactions of the quarks can no longer be neglected. In particular, the electric charge of the sea quarks cannot be ignored a priori without introducing an uncontrolled systematic uncertainty. I review some of the challenges encountered in going beyond the electroquenched approximation, either when the QED effects are included via reweighting à la RM123 or when they are included directly in the importance sampling.