Chiral effective field theory allows one to calculate the response of few-nucleon systems to external currents, both for currents that can be probed in the Standard Model and ones that only exist in Standard-Model extensions. In combination with state-of-the-art many-body methods, the constraints from chiral symmetry can then be implemented in nuclear structure factors that describe the response of atomic nuclei in direct-detection searches for dark matter. We review the present status of this approach, including the role of coherently enhanced two-body currents, the discrimination of dark matter candidates based on the nuclear response functions, and limits on Higgs-portal dark matter.