We present the MUFASA simulations, a new suite of cosmological hydrodynamic
simulations for
galaxy formation and intergalactic medium evolution, and describe some use
cases for MeerKAT
science. The MUFASA simulations use state of the art modeling techniques and
updated microphysics
prescriptions to produce among the most realistic descriptions of the galaxy
population
ever achieved numerically. Here we outline various avenues by which MUFASA will
be used
to help guide and interpret observations to be done with MeerKAT, focusing
particularly on the
LADUMA, MIGHTEE, MHONGOOSE, and MALS Key Project Surveys.