The Deep Underground Neutrino Experiment (DUNE) will pursue a broad program on neutrino physics and astrophysics with a staged 40 kt LAr detector at the Sanford Underground Research Facility (SURF) 1300 km from Fermilab. The scientific goals include neutrino oscillations studies with a powerful neutrino beam from Fermilab leading to determining the neutrino mass ordering and the measurement of the CP violating phase. The underground location of the DUNE far detector will allow undertaking searches for new phenomena and the detection of astrophysical processes involving neutrino emission. The observation of the neutrino signal from a core-collapse supernova in the DUNE LAr TPCs will provide unique and unprecedented information on the mechanism of supernovae in addition to enabling the search for new physics. In addition, DUNE will search for proton decay in the range of proton lifetimes predicted by a wide range of GUT models by virtue of its high detection efficiency and low background rates.