The KLOE-2 experiment at the INFN Laboratori Nazionali di Frascati (LNF) is currently taking data at the $e^+e^-$ DA$\Phi$NE collider which is implementing an innovative collision scheme based on a crab-waist configuration.
An integrated luminosity of $\sim4$~fb$^{-1}$ has been already collected by KLOE-2, and $\geq 5$~fb$^{-1}$ is in total expected by Spring 2018.
KLOE-2 represents the continuation of KLOE with an upgraded detector and an extended physics program which includes neutral kaon interferometry and test of discrete symmetries among the main topics.
Entangled neutral kaon pairs produced at DA$\Phi$NE are a unique tool to test discrete symmetries and quantum coherence at the utmost sensitivity, in particular strongly motivating the experimental searches of possible CPT violating effects, which would constitute an unambiguous signal of a New Physics framework.
The status of the latest ongoing analyses of KLOE/KLOE-2 data is reviewed. In particular a new preliminary measurement of the $K_S$ semileptonic charge asymmetry and related CPT tests are presented.