NU-CLEUS is a proposed cryogenic experiment to make precision measurements of coherent elastic neutrino-nucleus scattering at moderate distance from a nuclear power reactor. The use of ultra-low threshold gram-scale cryogenic calorimeters promises high-statistics measurements with miniaturized targets. Initially, NU-CLEUS will deploy a target array of 10 g while preparing for a scaling-up to 1 kg of total target mass. We discuss the physics potential resulting from such
a setup in terms of precise cross-section measurements in a previously unaccessible energy range. Results from a prototype target detector operated above ground are presented.