This contribution details results of recently completed searches for massive vector-like top and bottom quark partners using proton-proton collision data collected with the CMS detector at the CERN LHC at a center-of-mass energy of 13 TeV. Single and pair production of vector-like quarks are studied, with decays into a variety of final states, containing top and bottom quarks, electroweak gauge and Higgs bosons. Analyses utilize several categories of reconstructed objects, from multi-leptonic to fully hadronic final states. Improved exclusion limits on both the vector-like quark mass and cross sections are obtained, for combinations of the possible vector-like quark branching ratios.