The Fermi Masterclass is an international outreach event designed to give high-school students the unique opportunity to discover the world of High-Energy Astrophysics. Since 2017, following analogous experiences previously proposed mostly in France, various Italian universities and research institutes, guided by the National Institute for Nuclear Physics (INFN), organized a "full immersion" day of dedicated lectures and exercises in which students analysed real data collected by the LAT experiment aboard the Fermi satellite. Over the years, foreign institutes from Slovenia, Sweden and the U.S. also joined the effort, giving the students the unique opportunity to interact with each other as in real international collaborations.
The 4$^{th}$ edition of the Fermi Masterclass was scheduled to take place in April 2020. However, due to the pandemic emergency, the Masterclass was initially postponed, and finally took place as an online edition on December 10th, 2020.
Here we present the structure and organization of this first virtual event, including an interactive part of exercises accessible to the students through dedicated web platforms.