Signatures of new phenomena are abundant -- thanks to the new instrumentation launched into space and built on the ground. Modern technologies employed by those instruments provide measurements with unmatched precision, enabling searches for subtle signatures of dark matter (DM) and new physics in cosmic rays (CRs) and photon emissions. Understanding the conventional astrophysical backgrounds is vital in moving to the new territory. The state-of-the-art CR propagation code called GalProp is designed to address exactly this challenge. Having 25 years of development behind it, the GalProp framework has become a de-facto standard in astrophysics of CRs, diffuse photon emissions (radio- to $\gamma$-rays), and searches of new physics. GalProp uses information from astronomy, particle, and nuclear physics to predict CRs and their associated emissions and their polarization in a self-consistent manner -- it provides the modeling framework unifying the many results of individual measurements in physics and astronomy spanning in energy coverage, types of instrumentation, and the nature of detected species. The range of physical validity of the GalProp framework covers sub-keV--PeV energies for particles and from $\mu$eV--PeV for photons. Combining GalProp with HelMod, a heliospheric transport code, into a unified framework considerably extends its capabilities providing a consolidated description of CR transport from their sources to the near-Earth orbit. The framework and the datasets are public and are extensively used by many experimental collaborations, and by thousands of individual researchers worldwide for interpretation of their data and for making predictions. This paper details the latest updates to the GalProp framework, further developments of its initially auxiliary datasets that grew into independent studies of the Galactic structure -- distributions of gas, dust, radiation and magnetic fields as well as further extension of its capabilities.