We present the results of a first cycle of the unique Cultural Collisions programme run entirely online over one school year 2020/2021 in the South East Europe region. Cultural Collisions is a novel cross-disciplinary science engagement, networking and education programme designed to stimulate the interest of high school students in science by introducing the methods and concepts of art and creativity into their standard science studies. It is based on a unique collaboration of international, national and local partners (scientists, artists and educators), using modern communication tools which in particular facilitate the participation of inner city and rural communities. It provides access to, and is supported by, science centres and museums through workshops and exhibitions. Cultural Collisions Bosnia and Herzegovina brought together 11 working groups in 6 different Bosnian cities and was run entirely online. During a whole school year, a total of 130 students participated in workshops and 556 in complementary events, including virtual visits and public lectures. They were supported by a unique collaboration of their teachers, local artists, local and international scientists, and demonstrated strong interest and enthusiastic engagement. Their commitment and efforts have resulted in an enhancement of their skills, an improved understanding of big science questions, scientific methodology, and an enhanced ability to discover creative solutions to complex problems. Furthermore, the programme demonstrated that the creative approach to engage with scientific topics encourages an increase in the participation of girls. The program was organized by ORIGIN/CMS following the Cultural Collisions methodology of previous successful similar programs in Canada, Germany, Switzerland and Austria.