We show that assuming flavor violation in the first two generations
of sfermions in the decoupling limit leads to interesting consequences for proton decay in minimal SUSY-SU(5). We assume that decoupling sfermions lie within 30 TeV. The decay mode $p \to e^+ \pi^0$, which usually has sensitivity beyond that of DUNE and Hyper K is brought within the reach of these experiments due to the flavor mixing. The most dominant decay mode in minimal SUSY-SU(5) is $p \to K^+ \bar \nu_e$ which essentially rules this model out for this range of masses, is now able to survive due to cancellation from flavor mixing and further interestingly can be explored at DUNE and HyperK. Finally, partial decoupling has interesting consequences for the mode $p \to K^+ \bar \nu_\tau$ and becomes the most constrained mode.