We present recent progress on the Heavy-Flavor Non-Relativistic Evolution (HF-NRevo) framework, designed to describe leading-power fragmentation of heavy-flavored hadrons at moderate to large transverse momentum. Starting from NLO NRQCD calculations for all partonic channels into pseudoscalar quarkonia, we construct the NRFF1.0 collinear fragmentation functions via DGLAP evolution in a variable-flavor number scheme. We outline future prospects in the heavy-ion context, where HF-NRevo can serve as a baseline for modeling in-medium modifications of heavy-flavor fragmentation in nuclear collisions. Its accurate modeling of the partonic hierarchy and threshold effects makes it ideally suited to explore jet-quenching sensitivity, energy-loss mechanisms, and the emergence of medium-modified fragmentation functions in the quark-gluon plasma. These developments provide new handles for exploring heavy-flavor dynamics at the HL-LHC and future collider facilities.